Welcome from the Scientific Director

Neurodegenerative diseases are caused by a multifactorial process and a progressive degeneration that leads to neuronal death, affecting various cell populations in the central and/or peripheral nervous system. This neuronal loss results in a deterioration of functions affecting cognition, behavior, global or partial motor skills, sensory capacity, or, often, a combination of these abilities. At CIBERNED, we study the most prevalent diseases within this group, such as Alzheimer's disease and other degenerative dementias (such as Lewy body dementia, frontotemporal dementias, among others), Parkinson's disease, and other degenerative conditions associated with movement disorders such as Huntington's chorea, ataxias, and genetically inherited spastic paraparesis. We also focus on amyotrophic lateral sclerosis (ALS) and other neuromuscular disorders like peripheral neuropathies, myasthenia, or muscular dystrophies. Lastly, as an example of the complex relationship between neuroinflammation and neurodegeneration, we study multiple sclerosis and other inflammatory diseases of the central nervous system. In all these cases, our approach is directed toward Precision Medicine, with a special interest in the search for biomarkers and new therapeutic targets to support Personalized Medicine approaches.